• Park J.J.*, Codina A*, Ye, L.*, … Chen S. Double knockout CRISPR screen for cancer resistance to T cell cytotoxicity. Journal of Hematology & Oncology 2022. PDF
  • Song J.*, Chow R.D.*, Pena-Hernandez, M.*, Zhang L.*, … Chen S., Wilen C.B.**, Lee S.** LRRC15 inhibits SARS-CoV-2 cellular entry in trans. Plos Biology 2022. PDF
  • Fang Z., Monteiro V.S., Hahn A.M., Grubaugh N.D., Lucas C., Chen S. Bivalent mRNA vaccine booster induces robust antibody immunity against Omicron lineages BA.2, BA.2.12.1, BA.2.75 and BA.5. Cell Discovery 2022. PDF
  • Park JJ., Lee K.A.V., Lam S.Z., Tang K., Chen S. Genome Engineering for Next-Generation Cellular Immunotherapies. Biochemistry 2022. PDF
  • Na Z.*, Dai X.*, Zheng S., Bryant C.J., Loh K.H., Su X., … & Chen S. & Slavoff S.A.. Mapping subcellular localizations of unannotated microproteins and alternative proteins with MicroID. Mol. Cell 2022. PDF
  • Peng, L.*, Fang, Z.*, Renauer, P.A.*, McNamara, A., Park, J.J., Lin, Q., … Wilen, C. B. & Chen, S. Multiplexed LNP-mRNA vaccination against pathogenic coronavirus species. Cell Reports 2022. PDF
  • Fang, Z.*, Peng, L.*, Filler, R., Suzuki, K., McNamara, A., Lin, Q., … Wilen, C. B.** & Chen, S.** Omicron-specific mRNA vaccination alone and as a heterologous booster against SARS-CoV-2. Nature Communications 2022. doi: PDF
  • Fang, Z.*, Peng, L.*, Lucas C., Lin, Q., Zhou, L., Yang, L., Feng, Y., … Wilen, C. B. & Chen, S. (2022). Heterotypic vaccination responses against SARS-CoV-2 Omicron BA. 2. Cell Discovery 2022. PDF
  • Peng, L.*, Renauer, P. A.*, Ökten, A.*, Fang, Z.*, Park, J. J.*, Zhou, X.*, … Wilen, C. B.** & Chen, S**. Variant-specific vaccination induces systems immune responses and potent in vivo protection against SARS-CoV-2. Cell Reports Medicine 2022, 100634. 10.1016/j.xcrm.2022.100634 PDF
  • Peng, L.*, Hu, Y.*, Mankowski, M. C.*, Ren, P.*, Chen, R. E., Wei, J., … Wilen, C. B.**, Xiong, Y.** & Chen, S**. (2022). Monospecific and bispecific monoclonal SARS-CoV-2 neutralizing antibodies that maintain potency against B. 1.617. Nature Communications 2022. PDF
  • Ye, L.*, Park, J. J.*, Peng, L.*, Yang, Q.*, Chow, R. D., Dong, M. B., … & Chen, S. A genome-scale gain-of-function CRISPR screen in CD8 T cells identifies proline metabolism as a means to enhance CAR-T therapy. Cell Metabolism 2022. 10.1016/j.cmet.2022.02.009 PDF
  • Bock, C., Datlinger, P., Chardon, F., Coelho, M. A., Dong, M. B., Lawson, K. A., … & Zhuang, X. High-content CRISPR screening. Nature Reviews Methods Primers 2022. PDF
  • Fang Z*, Peng L*, Filler R, Suzuki K, McNamara A, Lin Q, Renauer PA, Yang L, Menasche B, Sanchez A, Ren P, Xiong Q, Strine M, Clark P, Lin C, Ko AI, Grubaugh ND, Wilen CB, Chen S. Omicron-specific mRNA vaccination alone and as a heterologous booster against SARS-CoV-2. bioRxiv 2022. doi: PDF
  • Park JJ, Codina A, Ye L, Lam S, Guo J, Clark P, Zhou X, Peng L, Chen S. Double knockout CRISPR screen in cancer resistance to T cell cytotoxicity. bioRxiv 2022. doi: PDF


  • Chow RD, Majety M, Chen S. The aging transcriptome and cellular landscape of the human lung in relation to SARS-CoV-2. Nature Communications 2021. doi:10.1038/s41467-020-20323-9. PDF
  • Park JJ, Chen S. Metaviromic identification of discriminative genomic features in SARS-CoV-2 using machine learning. Cell Patterns 2021. doi:10.1016/j.patter.2021.100407. PDF
  • Park JJ, Lee K, Lam S, Chen S. T cell receptor repertoire signatures associated with COVID-19 severity. bioRxiv (preprint) 2021. doi: https: 10.1101/2021.11.30.470640. PDF
  • Peng, L., Park, J.J., Fang, Z., Zhou, X., Dong, M.B., Xiong, Q., Lin, C. and Chen, S. Systems immune profiling of variant-specific vaccination against SARS-CoV-2. bioRxiv 2021. doi:10.1101/2021.12.02.471028. PDF
  • Peng L, Hu Y, Mankowski M, Ren P, Chen R, Wei J, Zhao M, Li T, Tripler T, Ye L, Chow R, Fang Z, Wu C, Dong MB, Cook M, Wang G, Clark P, Nelson B, Klein D, Sutton R, Diamond MS, Wilen CB, Xiong Y, Chen S. Monospecific and bispecific monoclonal SARS-CoV-2 neutralizing antibodies that maintain potency against B. 1.617. bioRxiv 2021. doi:10.1101/2021.12.21.473733. PDF
  • Dong MB, Tang K, Zhou X, Zhou JJ, Chen S. Tumor immunology CRISPR screening: present, past, and future. Trends in Cancer 2021.  doi: 10.1016/j.trecan.2021.11.009. PDF


  • Yuan S*, Peng L*, Park JJ, Hu Y, Devarkar SC, Dong MB, Shen Q, Wu S, Chen S**, Lomakin I**, Xiong Y**. Nonstructural protein 1 of SARS-CoV-2 is a potent pathogenicity factor redirecting host protein synthesis machinery toward viral RNA. Molecular Cell 2020. doi: 10.1016/j.molcel.2020.10.034. PDF
  • Chow RD*, Chen JS*, Shen J, and Chen S. A web tool for the design of prime-editing guide RNAs. Nature Biomedical Engineering 2020. doi: 10.1038/s41551-020-00622-8. PDF
  • Wang G*, Chow RD*, Zhu L*, Bai Z*, Ye L, Zhang F, Renauer PA, Dong MB, Dai X, Zhang X, Du Y, Cheng Y, Niu L, Chu Z, Kim K, Liao C, Clark P, Errami Y, Chen S. CRISPR-GEMM pooled mutagenic screening identifies KMT2D as a major modulator of immune checkpoint blockade. Cancer Discovery 2020. doi: 10.1158/2159-8290.CD-19-1448. PDF


  • Wang G*, Chow RD*, Bai Z, Zhu L, Errami Y, Dai X, Dong MB, Ye L, Zhang X, Renauer PA, Park JJ, Shen L, Ye H, Fuchs CS, Chen S. Multiplexed activation of endogenous genes by CRISPRa elicits potent antitumor immunity. Nature Immunology 2019. doi: 10.1038/s41590-019-0500-4. PDF
  • Ye L*, Park JJ*, Dong MB*, Yang Q, Chow RD, Peng L, Du Y, Guo J, Dai X, Wang G, Errami Y, Chen S. In vivo CRISPR screening in CD8 T cells with AAV-Sleeping Beauty hybrid vectors identifies membrane targets for improving immunotherapy for glioblastoma. Nature Biotechnology 2019. doi: 10.1038/s41587-019-0246-4. PDF
  • Dong MB*, Wang G*, Chow RD*, Ye L*, Zhu L, Dai X, Park JJ, Kim HR, Errami Y, Guzman CD, Zhou X, Chen KY, Renauer PA, Du Y, Shen J, Lam SZ, Zhou JJ, Lannin DR, Herbst RS, Chen S. Systematic Immunotherapy Target Discovery Using Genome-Scale In vivo CRISPR Screens in CD8 T Cells. Cell 2019. doi: 10.1016/j.cell.2019.07.044. PDF.
    in vitro screen raw count table
    in vivo screen raw count table
  • Chow RD*, Wang G*, Ye L*, Codina A, Kim HR, Shen L, Dong MB, Errami Y, Chen S. In vivo profiling of metastatic double knockouts through CRISPR-Cpf1 screens. Nature Methods 2019. doi: 10.1038/s41592-019-0371-5. PDF
  • Dai X*, Park JJ*, Du Y, Kim HR, Wang G, Errami Y, Chen S. One-step generation of modular CAR-T with AAV-Cpf1. Nature Methods 2019. doi: 10.1038/s41592-019-0329. PDF
  • Codina A*, Renauer PA*, Wang G*, Chow RD*, Park JJ**, Ye H**, Zhang K**, Dong M**, Gassaway B, Ye L, Errami Y, Shen L, Chang A, Jain D, Herbst RS, Bosenberg M, Rinehart J, Fan R, Chen S. Convergent identification and interrogation of tumor-intrinsic factors that modulate cancer immunity in vivo. Cell Systems 2019. 10.1016/j.cels.2019.01.004. PDF


  • Chow RD, Chen S. Sno-derived RNAs are prevalent molecular markers of cancer immunity. Oncogene. 2018 Aug 2. PDF
  • Ye L, Wang C, Hong L, Sun N, Chen D, Chen S*, Han F*. Programmable DNA repair with CRISPRa/i enhanced homology-directed repair efficiency with a single Cas9. Cell Discovery. 2018 Jul 24;4:46. PDF
  • Chow RD, Kim HR, Chen S. Programmable sequential mutagenesis by inducible Cpf1 crRNA array inversion. Nature Communications. 2018 May 15;9(1):1903. PDF
  • Chow RD, Chen S. Cancer CRISPR screens in vivo. Trends in Cancer. 2018 Mar 29. PDF
  • Wang G*, Chow RD*, Ye L, Guzman CD, Dai X, Dong MB, Zhang F, Sharp PA, Platt RJ, Chen S. Mapping a functional cancer genome atlas of tumor suppressors in mouse liver using AAV-CRISPR mediated direct in vivo screening. Science Advances. 2018 Feb 28;4(2). PDF


  • Chow RD*, Guzman CD*, Wang G*, Schmidt F*, Youngblood MW, Ye L, Errami Y, Dong MB, Martinez MA, Zhang S, Renauer P, Bilguvar K, Gunel M, Sharp PA, Zhang F, Platt RJ, Chen S. AAV-mediated direct in vivo CRISPR screen identifies functional suppressors in glioblastoma. Nature Neuroscience. 2017 Aug 14. PDF


  • Chen S*, Sanjana NE*, Zheng K, Shalem O, Lee K, Shi X, Scott DA, Song J, Pan JQ, Weissleder R, Lee H, Zhang F, Sharp PA. Genome-wide CRISPR screen in a mouse model of tumor growth and metastasis. Cell. 2015 Mar 12;160(6):1246-60. PDF


  • Platt RJ*, Chen S*, Zhou Y, Yim MJ, Swiech L, Kempton HR, Dahlman JE, Parnas O, Eisenhaure TM, Jovanovic M, Graham DB, Jhunjhunwala S, Heidenreich M, Xavier RJ, Langer R, Anderson DG, Hacohen N, Regev A, Feng G, Sharp PA, Zhang F. CRISPR-Cas9 knockin mice for genome editing and cancer modeling. Cell. 2014 Oct 9;159(2):440-55. PDF
  • Xue W*, Chen S*, Yin H*, Tammela T, Papagiannakopoulos T, Joshi NS, Cai W, Yang G, Bronson R, Crowley DG, Zhang F, Anderson DG, Sharp PA, Jacks T. CRISPR-mediated direct mutation of cancer genes in the mouse liver. Nature. 2014 Oct 16;514(7522):380-4. PDF
  • Chen S*, Xue Y*, Wu X, Le C, Bhutkar A, Bell EL, Zhang F, Langer R, Sharp PA. Global microRNA depletion suppresses tumor angiogenesis. Genes Dev. 2014 May 15;28(10):1054-67. PDF


  • Chen S, Krinsky BH, Long M. New genes as drivers of phenotypic evolution. Nat Rev Genet. 2013 Sep;14(9):645-60. PDF


  • Chen S*, Ni X*, Krinsky BH, Zhang YE, Vibranovski MD, White KP, Long M. Reshaping of global gene expression networks and sex-biased gene expression by integration of a young gene. EMBO J. 2012 Jun 13;31(12):2798-809. PDF
  • Chen S, Spletter M, Ni X, White KP, Luo L, Long M. Frequent recent origination of brain genes shaped the evolution of foraging behavior in Drosophila. Cell Rep. 2012 Feb 23;1(2):118-32. PDF


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