We seek a global understanding of the molecular factors controlling cancer progression and anti-tumor immunity. Towards this end, we utilize a diverse set of modern tools including high-throughput screening, in vivo CRISPR genome editing, animal models, synthetic biology, and bioinformatics. Our goal is to uncover novel insights in cancer and develop them into the next generation of therapeutics.

Our research is supported by:

-National Institutes of Health
-National Cancer Institute
-The Mary Kay Foundation
-Ludwig Family Foundation
-Melanoma Research Alliance
-St. Baldrick’s Foundation
-Breast Cancer Alliance
-Alliance for Cancer Gene Therapy
-Blavatnik Family Foundation
-Yale Cancer Center

-Cancer Research Institute
-Damon Runyon
-The V Foundation
-Sontag Foundation
-Chenevert Foundation
-Pershing Square Sohn Cancer Research Alliance

Latest Highlights

11/23/2021: Congrats to Jon for his paper in Cell Patterns, identifying discriminative genomic features in SARS-CoV-2 using machine learning!

01/04/2021: Congrats to Ryan and Medha for their paper in Nature Communications, describing age-associated features of the human lung and how they relate to SARS-CoV-2!

10/29/2020: Congrats to Vino, Jonathan, Matt and colleagues/collaborators for their paper in Molecular Cell, revealing how SARS-CoV-2 Nsp1 disrupts host translation!

9/28/2020: Congrats to Ryan, Johanna and collaborators for their paper in Nature Biomedical Engineering describing a web tool for designing prime-editing guide RNAs!

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