We seek a global understanding of the molecular factors controlling cancer progression and anti-tumor immunity. Towards this end, we utilize a diverse set of modern tools including high-throughput screening, in vivo CRISPR genome editing, animal models, synthetic biology, and bioinformatics. Our goal is to uncover novel insights in cancer and develop them into the next generation of therapeutics.

Our research is supported by:

-National Institutes of Health
-National Cancer Institute
-The Mary Kay Foundation
-Ludwig Family Foundation
-Melanoma Research Alliance
-St. Baldrick’s Foundation
-Breast Cancer Alliance
-Alliance for Cancer Gene Therapy
-Blavatnik Family Foundation
-Yale Cancer Center

-Cancer Research Institute
-Damon Runyon
-The V Foundation
-Sontag Foundation
-Chenevert Foundation
-Pershing Square Sohn Cancer Research Alliance

Latest Highlights

03/07/2023: Congrats to Zhenhao Fang, Valter Monteiro and colleagues for their paper in Cell Research, describing a new Monkeypox (Mpox) mRNA vaccine candidate!

01/26/2023: Congrats to Xiaoyun, Jon, Yaying, Zhenkun, Stanley and colleagues for their paper in Nature Biotechnology, describing Massively parallel knock-in engineering of human T cells!

01/12/2023: Congrats to Ping, Vino and colleagues for their paper in Cell Chemical Biology, describing a technology for generating human monoclonal antibody, RAMIHM!

12/01/2022: Congrats to Jon, Adan, and Lupeng for their paper in Journal of Hematology & Oncology, describing a double KO screen in cancer cells, CADRE!

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