We seek a global understanding of the molecular factors controlling cancer progression and anti-tumor immunity. Towards this end, we utilize a diverse set of modern tools including high-throughput screening, in vivo CRISPR genome editing, animal models, synthetic biology, and bioinformatics. Our goal is to uncover novel insights in cancer and develop them into the next generation of therapeutics.

Our research is supported by:

-National Institutes of Health
-National Cancer Institute
-The Mary Kay Foundation
-Ludwig Family Foundation
-Melanoma Research Alliance
-St. Baldrick’s Foundation
-Breast Cancer Alliance
-Alliance for Cancer Gene Therapy
-Blavatnik Family Foundation
-Yale Cancer Center

-Cancer Research Institute
-Damon Runyon
-The V Foundation
-Sontag Foundation
-Chenevert Foundation
-Pershing Square Sohn Cancer Research Alliance

Latest Highlights

11/04/2022: Congrats to Xiaoyun, Jon, Yaying, Zhenkun, Stanley and colleagues for their paper in Nature Biotechnology, describing Massively parallel knock-in engineering of human T cells!

07/19/2022: Congrats to Zane, Vino and colleagues for their paper in Cell Discovery, describing heterotypic vaccination responses to SARS-CoV-2 BA.2!

07/07/2022: Congrats to Chuanpeng for getting the Yale University and Boehringer Ingelheim Biomedical Data Science Fellowship!

06/06/2022: Congrats to Zane, Vino and collaborators for their paper in Nature Communications describing Omicron specific mRNA vaccination alone and as a heterologous booster against SARS-CoV-2!

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