We seek a global understanding of the molecular factors controlling cancer progression and anti-tumor immunity. Towards this end, we utilize a diverse set of modern tools including high-throughput screening, in vivo CRISPR genome editing, animal models, synthetic biology, and bioinformatics. Our goal is to uncover novel insights in cancer and develop them into the next generation of therapeutics.
Our research is supported by:
-National Institutes of Health
-National Cancer Institute
-The Mary Kay Foundation
-Ludwig Family Foundation
-Melanoma Research Alliance
-St. Baldrick’s Foundation
-Breast Cancer Alliance
-Alliance for Cancer Gene Therapy
-Blavatnik Family Foundation
-Yale Cancer Center
-Cancer Research Institute
-AACR
-Damon Runyon
-The V Foundation
-DoD
-Sontag Foundation
-Chenevert Foundation
-Pershing Square Sohn Cancer Research Alliance
-JDRF
-LRA
Latest Highlights
03/20/2025: Congrats to Kaiyuan Tang, Liqun Zhou, Matthew Dong, Xiaoyu Zhou and colleagues for their paper in Nature Biomedical Engineering, describing Cas12a-knock-in mice for multiplexed genome editing, disease modelling and immune-cell engineering!
03/04/2025: Congrats to Chuanpeng Dong, Feifei Zhang and colleagues for their paper in Cell Patterns, describing Sensitive detection of synthetic response to cancer immunotherapy driven by gene paralog pairs!
01/15/2025: Congrats to Feifei Zhang, Ryan Chow, Guangchuan Wang and colleagues for their paper in Nature Biotechnology, describing Multiplexed inhibition of immunosuppressive genes with Cas13d for combinatorial cancer immunotherapy!
08/12/2024: Congrats to Lei Peng, Giacomo Sferruzza, Luojia Yang and colleagues for their review paper in Cellular & Molecular Immunology, describing CAR-T and CAR-NK as cellular cancer immunotherapy for solid tumors!
Lab video
Sidi Chen Lab 