March 2025:
Congrats on Kaiyuan’s new paper published in Nature Biomedical Engineering! News on our new paper:
Yale News:
https://news.yale.edu/2025/03/20/new-crispr-tool-enables-more-seamless-gene-editing-and-improved-disease-modeling
Additional news about our new paper:
https://www.news-medical.net/news/20250320/Yale-scientists-develop-advanced-CRISPR-tool-to-study-complex-genetic-interactions.aspx
https://www.msn.com/en-gb/health/other/a-next-gen-crispr-tool-just-dropped/ar-AA1Bos4R
https://phys.org/news/2025-03-crispr-tool-enables-seamless-gene.html
https://www.sciencedaily.com/releases/2025/03/250320145239.htm
https://www.technologynetworks.com/tn/news/new-crispr-technology-enhances-genetic-interaction-research-in-disease-397502
January 2025:
Congrats on Feifei’s new paper published on Nature Biotechnology! News and comments on our new paper:
Yale News about our new Nature Biotechnology paper: https://news.yale.edu/2025/01/16/multi-target-approach-counters-tumor-growth-several-cancers
Additional news about our new paper:
https://www.news-medical.net/news/20250117/New-approach-shows-promise-in-fighting-multiple-cancers.aspx
https://www.stemcellsciencenews.com/newsletter/234726/
https://ecancer.org/en/news/25896-multi-target-approach-counters-tumour-growth-in-several-cancers
https://www.miragenews.com/multi-target-strategy-halts-tumor-growth-in-1392428/
Auguest 2024:
Congrats to Liqun on awarding Lo Graduate Fellowship for Excellence in Stem Cell Research!
https://medicine.yale.edu/stemcell/education/lofellows/?tab=2021
July 2024:
– Sidi and Chuanpeng presented at AIME24, International Conference of AI in Medicine
Dr. Chen was invited as a panelist together with Drs. James Cai, Jake Chen, Katie Zhu and Yves Lussier, to lead the discussion on AI for drug discovery at AIME 2024 (22nd International Conference of AI in Medicine) in Salt Lake City, Utah, from July 9-12. The panelists focused on the potential of AI in drug discovery and development, highlighting its applications in understanding fundamental biology, disease mechanisms, finding new approaches for immunotherapy, and improving patient outcomes. They emphasized the importance of collaboration between academia and industry, leveraging each other’s strengths to develop innovative solutions for patients. The speakers also discussed the need for comprehensive data, models, and ecosystems to accelerate drug development, and the potential of integrating AI and multi-omics data to overcome resistance mechanisms. Dr. Sidi Chen also spoke about integrating AI into cracking the codes of life, drug discovery, and challenges. He discussed using AI to develop algorithms for drug development and cell and gene therapy, and emphasized the importance of curiosity and AI in scientific research.
Jun 2024:
– Sidi comments (independent expert comment) on ASCO GPC3 AstraZeneca trial that showed good efficacy of CAR-T cells against solid tumor (liver cancer). https://www.statnews.com/2024/06/03/liver-cancer-car-t-astrazeneca-asco/
May 2024:
– Congrats to Harry on winning the Best Poster Presentation Award at the 9th Annual Biophysics and Structural Biology Symposium at Yale University!
April 2024:
– Congrats for the first patent issued for our lab! Platform for T lymphocyte genome engineering and in vivo high-throughput screening thereof. https://patents.google.com/patent/US11926839B2/en
March 2024:
– Congrats for Ariel getting an NIH/NCI K99/R00 award!
– Congrats to Meizhu on her new job as a senior scientist at Cell Therapy Division, oncology cell therapy unit, AstraZeneca! All the best in her new job!
– Lab’s patent application related T cell engineering and screening has been granted! Platform for T lymphocyte genome engineering and in vivo high-throughput screening thereof. Granted patent, 2024. https://patents.google.com/patent/US11926839B2/en
February 2024:
– Welcome Stellan Lee, Elena Im, Aaron Liu to the lab!
– Congrats to Harry on the acceptance of his poster for the RECOMB conference at MIT and for being awarded the Yale PEB travel grant!
September 2023:
– Welcome Hans Zhao for rotation in the lab!
July 2023:
– Welcome Xiaolong Tian to the lab!
– Welcome Carrie Wen, Kawthar Al Janabi, Josephine Burdekin to the lab!
-Congrats to Josephine, Luciano, Kawthar for winning various summer research scholarship
June 2023:
-Congrats to Wenlong Dai on his new faculty position at Nanjing Medical University! All the best in his new job!
– Welcome Luciano Romero to the lab!
-Congrats to Xiaoyun Dai on her new faculty position at WestLake University! All the best in her new job!
May 2023:
-Congrats to Xinyu on his Jane Coffin Childs fellowship and Leslie H. Warner fellowship!
-Congrats to Zane Fang on the Best Flash Talk award on YPA symposium 2023!
-Congrats to Medha who received two prestigious award during graduation ceremony: Yale MCDB Boell prize (for excellence in research) and the Yale MCDB Belknap prize (for academic excellence in biological studies). https://mcdb.yale.edu/undergraduate-prizes-and-awards
April 2023:
-Congrats to Xiaoyu (Ariel) Zhou on the Best Oral Presenter award on HTI 2023! Well deserved!
– Welcome Binfan Chen to the lab!
March 2023:
-Welcome Jake and Harry for rotation in the lab.
January 2023:
-Congrats on Xiaoyun’s new paper published on Nature Biotechnology! News and comments on our new paper:
https://www.nature.com/articles/s41587-023-01664-4
October 2022:
-Welcome Xinyu Ling to the lab!
September 2022:
-Welcome Shawn Lin to the lab!
August 2022:
-Welcome Zac and Emma to the lab!
July 2022:
-Welcome Chuanpeng Dong to the lab!
May 2022:
-Our alumni Gabby Gabel is graduating with high honors (majoring in biology and society with a minor in global health and law) from Cornell next month. After graduation, will be working for Morgan Stanley in NYC. Congrats!
Apr 2022:
-Congrats to Dr. Paul Renauer for his successful thesis defense!
Mar 2022:
-Welcome Liqun for joining the lab
-Welcome Luojia for joining the lab
-Welcome Zhangliang for rotation
-Welcome Yanzhi for rotation
-Congrats on Lupeng, Jon, Vino, QJ for Cell metabolism paper:
https://news.yale.edu/2022/03/10/yale-scientists-supercharge-cancer-fighting-t-cells
https://www.sciencedaily.com/releases/2022/03/220310170827.htm
https://www.technologynetworks.com/cancer-research/news/supercharging-cancer-fighting-t-cells-359476
https://medicalxpress.com/news/2022-03-scientists-supercharge-cancer-fighting-cells.html
Jan 2022:
-Welcome Liqun for rotation
-Welcome Luojia for rotation
November 2021:
-Congrats to Dr. Jonathan Park for a successful thesis defense!
-Congrats to Jon for his single-first-author paper published on Cell Patterns!
October 2021:
-Congrats to Dr. Ryan Chow for a successful thesis defense!
-Congrats to Dr. Matt Dong for successfully defending his thesis!
September 2021:
-Congrats to Nipun on being selected for the Holman Pathway Postdoctoral Fellowship!
-Congrats to Jon for winning “people’s choice” presentation award at NCI Cancer Systems Biology meeting.
-Welcome Jared and Angie to the lab!
August 2021:
-Welcome our new members Skylar from Berkeley and Shan from Munich/Germany !
July 2021:
-Congrats to Lupeng on securing a faculty / PI position!
June 2021:
-Congrats to Medha, Emily, Devin, Erica and Arianny for winning various summer research fellowships! Welcome our new undergrads! Enjoy the summer!
May 2021:
-Welcome Zane and Wenlong to our lab!
-Congrats to Class of 2021 Johanna, Jerry, Stanley and Viola, our awesome seniors!
-Congrats to Johanna on receiving the MCDB Boell Prize!
April 2021:
-Welcome to Kaiyuan, a new MCGD PhD student who joined our lab!
-Congrats to Ryan for receiving the Paul & Daisy Soros Fellowship for New Americans! YSM article, profile
January 2021:
-Congrats to Ryan and Medha for their paper in Nature Communications!
-Farewell to Guangchuan, Youssef, and Yaying! Guangchuan is now a Professor at the Shanghai Institute of Biochemistry and Cell Biology. Youssef is now an Assistant Professor at Tulane University. Yaying is now a Surgeon at Tongji Hospital.
December 2020:
-Welcome Nipun to the lab!
-Congrats to Dr. Adan on his successful thesis defense!
October 2020:
-Welcome Andrew, Sophia, and Kazushi to the lab!
-Congrats to Vino, Jon, Matt, and colleagues/collaborators for their paper in Molecular Cell!
September 2020:
-Congrats to Ryan, Johanna and colleagues for their paper in Nature Biomedical Engineering! pegFinder was mentioned in a Technology Feature in Nature Methods.
August 2020:
-Welcome Meizhu to the lab!
-Congrats to Guangchuan, Ryan, Lvyun, Zhigang, and colleagues for their paper in Cancer Discovery!
-Congratulations to Guangchuan for his new position as a Professor at the Chinese Academy of Sciences, Cell Biology Institute!
-Congrats to Paul for receiving the Lo Fellowship for Excellence in Stem Cell Research!
-Congrats to Jonathan for his bioRxiv preprint on metaviromic machine learning analysis! https://www.biorxiv.org/content/10.1101/2020.08.13.248575v1
-Congrats to Vino, Jonathan, and Matt for their bioRxiv preprint on SARS-CoV-2 Nsp1 in collaboration with Yong Xiong’s lab! https://www.biorxiv.org/content/10.1101/2020.08.09.243451v1
May 2020:
-Congrats to Krista on receiving the MCDB Boell Prize!
-Congrats to Alon on receiving the MCDB Belknap Prize!
-Congrats to Stanley on receiving the Domestic Summer Award (DSA)!
-Congrats to Won-Ho for the Dean’s Research Fellowship!
-Congrats to Medha on receiving the First Year Online Research Fellowship!
-Our prime editing pegRNA designer web portal is online! pegfinder.sidichenlab.org
Accompanying bioRxiv manuscript: PDF
April 2020:
-Sidi is chosen as the 2020 UChicago MBSAA Distinguished Alumni Award for Early Achievement! https://mbsaa.uchicago.edu/2020/04/uchicago-mbsaa-alumni-awards-2020/
-Congrats to Alon for his successful master’s thesis defense and his acceptance to the Tri-Institutional PhD program at Rockefeller/MSK/Cornell!
-Congrats to Erting for her acceptance into the UChicago Institute of Molecular Engineering program!
-Best wishes for Chris as a consultant with Boston Consulting Group (BCG)!
-Congrats to Johanna for receiving the Alexander Hixon fellowship!
-Congrats to Ryan for his bioRxiv preprint on the relationship between the aging lung and SARS-CoV-2! https://www.biorxiv.org/content/10.1101/2020.04.07.030684v2
-Congrats to Skylar Ford on her admission to UPenn!
March 2020:
-Sidi receives the Era of Hope Scholar Award from the Department of Defense! https://publichealth.yale.edu/biostat/news-article/22951/
February 2020:
-Ryan receives an F30 fellowship from NIH/NCI!
-Johanna is selected for the Amgen Summer Fellowship!
January 2020:
-Welcome Ping, Alan, and Victor to the lab!
November 2019:
-Welcome Feifei to the lab!
October 2019:
-Congrats to Guangchuan, Ryan and colleagues for their paper now out in Nature Immunology!
https://www.nature.com/articles/s41590-019-0500-4
Other selected news of MAEGI
1, 2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 12,13,14,15,16,17,18,19,20,21,22
– Welcome Dr. Cun Liao as a visiting scholar
September 2019:
-Congrats to Lupeng, Jonathan, Matt and colleagues for their paper now out in Nature Biotechnology!
– Welcome Dr. Qin Han as a visiting / sabatical Professor
August 2019:
-Congrats to Matt, Guangchuan, Ryan, Lupeng and colleagues for their paper now out in Cell !
- https://www.cell.com/cell/fulltext/S0092-8674(19)30844-X
- https://news.yale.edu/2019/08/22/genome-screen-uncovers-new-targets-cancer-immunotherapy
-Welcome Alon, Josh and WonHo as Yale College Students for Research
July 2019:
-Welcome Zhiyuan Chu (Visiting Undergraduate Student) and Erting Tang (Visiting Undergraduate Student) to the lab!
June 2019:
-Welcome Paul Clark (Senior Scientist), Kristin Kim (Visiting Undergraduate Student), and Skylar Ford (High School Student) to the lab!
-Xiaoyun wins the Revson senior fellowship for her project on CAR-T development! http://revsonfoundation.org/grants/category/biomedical-research/
May 2019:
-Congrats to Sidi for being named a 2019 Blavatnik Awardee! https://blavatnik.ocr.yale.edu/awardees
-Lei Vino Peng joined the lab as a postdoc!
-Adan is awarded an F31 fellowship from NIH/NCI!
March 2019:
-Xiaoyu Ariel Zhou joined the lab as a postdoc!
-Congrats to Ryan, Guangchuan, Lupeng and colleagues for their paper now out in Nature Methods! https://www.ncbi.nlm.nih.gov/pubmed/30962622
February 2019:
-Congrats to Xiaoyun, Jonathan and colleagues for their paper now out in Nature Methods! https://www.ncbi.nlm.nih.gov/pubmed/30804551
-Congrats to Adan, Paul, Guangchuan, Ryan and colleagues for their paper now out in Cell Systems! https://www.ncbi.nlm.nih.gov/pubmed/30797773
-Website is re-created via WordPress
-Sidi receives NCI support to model and identify cancer drivers and immunotherapy modulators
January 2019:
-Sidi is named as an Innovator under 35 in Biotechnology & Medicine (China) by the MIT Technology Review! Link
November 2018:
-Dr. Lvyun Zhu joined the lab as a visiting professor
-Sidi receives support to solve an NCI provocative question
September 2018:
-Sidi is awarded an NIH Director’s New Innovator Award (DP2)! Link
https://commonfund.nih.gov/newinnovator/AwardRecipients
-Sidi is named a Distinguished Scientist by the Sontag Foundation! Link http://www.sontagfoundation.org/recipients/sidi-chen/
August 2018:
-Yaying Du joined the lab as a postdoc!
-Lab receives support from The Mary Kay Foundation
March 2018:
-Li Zhang joined the lab as an associate research scientist!
-Quanjun Yang joined the lab as an associate research scientist!
January 2018:
-Congrats for Guangchuan and Ryan for their Science Advances paper! https://www.ncbi.nlm.nih.gov/pubmed/29503867
December 2017:
-Dr. Zhigang Bai joined the lab as a visiting professor
August 2017:
-Congrats to Ryan, Chris and Guangchuan, together with Randy and Florian at ETH, for their Nature Neuroscience paper! https://www.ncbi.nlm.nih.gov/pubmed/28805815
-Jonathan Park joined the lab as an MD-PhD student
-Ray Kim joined the lab as a technician
-Paul Renauer joined the lab as a PhD student
-Lupeng Ye joined the lab as a postdoc
-Krista Chen, Stanley Lam, Johanna Shen and Jerry Zhou joined the lab
-Lab receives support from St-Baldrick’s Foundation, Breast Cancer Alliance, Cancer Research Institute, DoD, and The V Foundation
April 2017:
-Sidi is awarded a NextGen Grant for Transformative Cancer Research by the AACR! Link https://www.aacr.org/Funding/PAGES/NEXTGEN-GRANT-RECIPIENTS.ASPX#Chen
-Guangchuan is awarded the CRI Irvington fellowship for immunotherapy research! http://www.cancerresearch.org/scientists/cri-funding-directory/guangchuan-wang-phd
2016:
-Ryan Chow joined the lab as an MD-PhD student
-Guangchuan receives RJ Anderson Postdoctoral Fellowship
-Guangchuan Wang, Youssef Errami and Xiaoyun Dai joined the lab as postdocs
-Adan Codina and Chris Guzman joined the lab as PhD students
-Michael Martinez joined the lab as a technician
-Lab receives support from Melanoma Research Alliance and American Cancer Society
2015:
-Matthew Dong joined the lab as an MD-PhD student
-Lab receives support from Damon Runyon Cancer Research Foundation
-Lab Started!
Sidi Chen Lab 